pentobarbital will lessen the extent or influence of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.pentobarbital will lessen the level or influence of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Advisable atogepant dosage with concomitant use of solid or reas